NFL Blitz 2000 was the first time the NFL Blitz series had crossed over onto the Dreamcast platform. It had previously appeared in arcades and on home and handheld platforms such as the PC, PlayStation, Nintendo 64 and Game Boy Color.
- In episode ten of Button Mashing, Jeff proclaimed that he and his life long rival Vince were the best NFL Blitz players on the planet. They had an intense battle but in the end Jeff was the victor.
- The Denver Broncos have the highest stats of any team in the game.